There are good answers about differentiation from stem cells, process governed by the evolutionary determined genetic information stored within the cell itself. This genetic information was/is influenced by environment but that influence tends to be slow and subtle.

I have another answer to contribute. Metastatic cancer cells. These are cells which detach from primary tumors in any part of the body, then have to break into the lymph or blood and then they in a sense "decide" where they want to settle. We now know they'll have preferences: some cancers will metastase to liver, some to lung, some to brain; but before they do so, these cells will literally circle around the body, searching for a "perfect spot". Once they find it, they settle, often entirely changing their O.G. tumorous behaviour in the process which in return makes them super unpredictable and hard to kill. And all it takes is one wandering cell.

I started Confessions of a Crap Artist by Phillip K. Dick and am not yet sure how I feel about it. Also started Tai-Pan in the urge to keep Shōgun vibe in my life after literally devouring the book, but Tai-Pan didn't feel the same. Is on hold for now till I forget Shōgun a bit.

I sometimes wish I could go back in time just to read some of the books for the first time again. Monte Cristo would be at the very top of that time-travel agenda. Enjoy the ride!

I missed this in the news, then saw link refers to Kronen Zeitung report which is not a great newspaper to cite so thought for sure it cannot be entirely true? But it is! And here another link from Die Presse (google translate works fine here) which tells us it was not a jerk dad who brought his kid to drill holes but an idiot mom.

Interesting. As women tend to combat vaginal dryness later in life, guidelines like these are especially needed there. Pretty sure you very easily fall into a vicious circle of lubing, ruining cells which produce any remaining lube -> lubing even more. I guess the bottom line is to buy water-based lubes with some sort of an organic "gel" source and avoid propylene glycol/tons of glycerine/detergets (though those are harder to detect by name).

is probably even margarine in this case

This is pretty interesting. I mean I've seen dogs dream vividly and am not quite sure how much I believe all them Babe the Pig-alike movies. :)

But I think the definition of a thought is a problem here. Everything we say (or contemplate of saying or trying to remember) is also a thought which precedes our verbal output. Those thoughts will inevitably be in a language of our preference. And actually in process of learning a new language that is often times the pivotal point - once your thoughts switch to a new language, you know you adapted it.

Also -1 here. I was convinced throughout my studies that my university was being super cheap on the projectors, getting always some shitty, soft ones. Ranted about it the whole time. Wish it was the beamers.

I think it's Lay it on me by Vance Joy. It has a part about him being sad, then there is love, and then an instrumental chorus to which I dance to (given a chance). I guess I find it pretty uplifting.

I am 10% into Lonesome Dove. Many people swear by it and to me has East of Eden vibes. I find the story a little slow but then there were a couple of scenes (all of which involved pigs) that made me laugh out loud. So far - worth it.

I'll suggest you what another user here on Lemmy suggested to me: Replay by Ken Grimwood. Topic is re-living life, there is a love story involved, relatively short and easily written but good - you won't need much brain to keep track of what's up but it is still a quality read.

I'll have to try them out now. And thanks for discovering Athlete to me, this was extremely useful.

No! I buy GAP often and never any of damn tracking engines offered me Athlete. I just checked and I can actually order it, so that great! I don't mind paying a bit more when I know it's good. That being said, lululemon I still haven't tried out due to the price. Would you recommend them? Are they that good?

Did not expect this post to survive to a point of obtaining more details. :)

• yes, I love GAP fit short. They are the most comfortable ones for me. However, they have side pockets (which I love when I am doing sports) but that gives away they are sporty. Am looking for something more versatile.
• Yes, I am. Just figured cotton(mix) might go better with shirts (big fan of oversized stripe/Hawaiian shirts + tops under)
• And am in Europe and have access to many brands, but you are correct, to the American limited.

Thanks for your time!

I think my hand-wash-only, pure-wool sweater believes by now that the bottom of the wash bin is where it belongs.

This is beautifully said. There had been moments in my life when I'd be so very happy that I would indeed close my eyes, take a deep breath and appreciate the moment. When there is nothing to bug you in the back of your mind to ruin the setting, such moments are beautiful and I agree, could be described as pure joy.

Also, metals can easily accommodate varying number of electrons in the electron shells of their atoms and still be stable. That makes them very good to quickly store and release electrons which means they can help say transfer molecules around (iron for transport of gasses), scavenge free radicals (e.g. manganese) etc.

This is excellent!

It can really depend where you live so I think the first advise is to take it easy on yourself.

• It is ok to combine ways of transports, say cycle to the first train/bus then load the bike on it/park at the station
• Start with a sturdier bike, the one which is bigger and more visible in traffic and gives you a better sense of control.
• don't expect cars to respect you because you cycle or to know what to do around you. Bad drivers are everywhere. Don't try to prove points. Safety is more important than ego.
• get yourself a good, large backpack. This will be your new back seat
• Take taxi/uber when needed. I once arrived to a friend's wedding held out of town in a taxi and literally everybody I knew there looked at me as I was either a fool or a millioner. The bill was like 35$. Way cheaper than owning a car.

Lastly, enjoy how good you will feel. Climate protection and all that is great but your body will love you for it and you will feel it. Good luck

Yes!! Funny story, I learned about redwood from a boardgame when I was six and thought they are some trees from this magic game world that don't exist in real life. You can imagine how excited I was once I realized they are real and more so when I first saw them! Californian ones are the most impressive, no debate there, but I actually found quite a few across Europe too, often in super random places. So maybe you will also find some around where you live? You never know.

Lived in Bay Area for some time and been up to the Redwood National park but not to Santa Cruz! Just checked it out and now I have another reason to visit again. Honestly, I would have even stayed there - NorthCal's nature is simply breathtaking - but unfortunatelly so are the living costs around there.

Trees! Those big, old giants which make you feel like they are indeed harboring some ancient wisdom, being there, in the same spot years before you, barely brushed by the passing of time. And then if they are evergreen not even season affects them - they just keep on existing, all tall and gracious. How awesome is that.

Does anyone have an answer why this is? This question bugged me already before and now again. Thanks OP

Not to mention academic/research text where authors are actually forced to pay to publish, only to have the articles end up behind a pay wall of given journal. If the authors want their papers freely available, they have to pay extra fees to the journal (we are talking thousands of dollars scale). Not a cent goes back to the authors or even research funding bodies. Long live Libgen!

Make trains cheaper goddammit

Yes, yes, you are totally correct - delivery can make all the difference.

But I have to add that my main problem is that I am a scientist and big part of my job is to read immense amount of literature and memorize/connect often obscure terms. So when I read for pleasure (I love my job, but still) what I tend to enjoy the most are character heavy, emotional books with beautiful prose, written by people with deep understanding of life. Quite opposite to the academic literature.

So you are right, yes, this slog issue is not restricted to SF (e.g. I don't read epic fantasy either; GoT and LOTR books I skipped myself as well), but SF in particular is something I really want to dig deeper, as there the ideas challenge my brain and remain lingering far after I finish the piece.

But! - I prefer to do it without being forced into a memory challenge. Because if I start and within the first two pages there are 15 names and 3 planets and lots of traveling (i really damn hate descriptions of pure traveling, like please lets just skip that part) then I lose interest in the main idea and the ideas are what I am after.

So Tldr yes, you are absolutely right, it is also the prose and the delivery, but still no prose or delivery would keep me long motivated or make me deeply enjoy reading work which has too many names or weird, invented terms.

It doesn't refer to the interaction of liver with stones. The bile acids are produced in liver then transported to the gallbladder, where they are stored and released into the intestine when needed. The whole role of gallbladder is to accept and release the bile salts, the "stuff that liver makes". But then sometimes gallbladder makes stones and it has to be removed because of it.

Never too late for good recommendations! I am happy such a good collection of suggestions was made, not just for me but for everyone. Thanks for contributing!

My adult swinging friend, try the slide too if you ever get a chance. Also brilliant.

This is so damn good. I maked these, poor gally <3

I think to really solve this we will need to wait for the kids from this generation to grow up, and those who "figure it out" teach others how to do it, through a (hopefully adapted) educational system or otherwise. Because, to be honest, we don't really know what this is like. We think we do, but we don't, not really.

Cycling. I don't (yet) have all the fensi equipment nor an expensive bike and don't do long, exercise-like laps. It is much more incorporated into my daily life. I have an oldschool road bike which I use for my commute and then every day after work go around the city with it for some hours (with small breaks for say shopping/eating; ca. 25-30 km per day). Longer rides on the weekends (average ca 100-120 km per weekend). Never was keen on sports but was always into little daily adventures and this combines the two. Last time: yesterday.

Hey I just finished the Replay and came to thank you again for mentioning it. Such an amazing book, absolutely one of my best reads so far. Cannot believe it is not more popular. Not only the plot got me, but also the way it was written, so... Human and intelligent. Also there is often quite some interesting info and emotional maturity in the dialogs, and yet they never felt forced, as those well-thought-through-exchanges sometimes tend to be. Just excellent. But gotta say: for once, for freaking once, the main character of time travel invests in stocks. I mean, come on, finally!

Anyways, you literally nailed it with recommending me this one. Will also look up now the other two from the list. Thanks again!

Thanks, especially for summarizing other comments. Also, sorry for my 1000 years of solitude misspell... Marques didn't dream as big as Asimov haha

She keeps popping up so I think I really have to check her out. :)

The Martian I am saving as one of those cannot go wrong books, in case i ever run into reading blockage. But Expanse i didn't check out. Will do now. Thanks

I haven't. I thought I wasn't really into short stories... Till I discovered Ray Bradbury. Now I am very much into short stories. So will give Asimov a try for sure.

Just finished it a week ago. That prose... From another planet.

Exactly this. Thank you. :)

You do know nothing is black and white in life, right?

Anyways, I wouldn't put Dune as my 5* read, but I did enjoy it. I only read the main part of the main Dune book, not the whole series, prequels etc. Also, it is mainly set on one planet.