Can’t get OpenRGB to Change Anything

I have the latest stable version. I cannot get the program to actually change any LEDs off my MSI mobo. I also have Corsair RAM and that works just fine. I have 3 RGB fans and two strips all chained to a single ARGB header. The system of course starts with Rainbow but nothing I do changes anything, no matter how I resize the zone (I believe I have either 44 or 32 total LEDs.) Even in Mystic Light itself it doesn’t work! ORGB recognizes my MS board fine on USB; but no changes actually happen. I have a Z490A-PRO. Any help would be much appreciated; I’m one of the many that never want to open the bloated MSI center ever again.